Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)
About this study
The goal of this study is to learn more about how exercise might lower the risk of developing breast cancer in women with dense breast tissue by studying changes that occur in breast tissue and blood as a result of participating in an exercise program. The names of the study groups in this study are: * Exercise Training Group * Waitlist Control Group
- Condition
- Breast Cancer, Breast Cancer Female
- Tested
- Exercise Training Program
- Sponsor
- Dana-Farber Cancer Institute
Who can join
- Age
- 18 to 59 years
- Sex
- Female only
- Healthy volunteers
- Accepted
Inclusion 10
- Minimum age: 18 years
- Maximum age: 59 years
- Eligible sex: Female
- Study condition: Breast Cancer, Breast Cancer Female
- Women aged 18-59
- Heterogeneously dense/extremely dense (BIRADS 3 or 4) breast tissue on mammogram within the past 12 months
- Physically inactive; engaging in \<60 minutes of moderate or vigorous intensity exercise per week, as assessed by Godin Leisure Time screener
- Not pregnant or breastfeeding
- English speaking and able to read English. Investigators are only enrolling English-speaking participants to this study at this time due to the fact that investigators currently only have English-speaking exercise trainers with the proper qualifications to conduct the exercise training
- Written informed consent prior to any study-related procedures
Exclusion 9
- Self-reported inability to walk 2 blocks (at any pace)
- Prior history of breast cancer; prior DCIS is allowable as long as participant is not taking endocrine therapy and has at least 1 breast that has not been irradiated
- On oral or implantable hormonal contraceptives, postmenopausal hormone replacement therapy, a selective estrogen receptor modulator or an aromatase inhibitor; Mirena or other IUD is acceptable
- Consistent strength training in the past 3 months
- Use of weightloss drugs
- Cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate exercise.
- Examples would include unstable angina, recent myocardial infarction, oxygen-dependent pulmonary disease, and osteoarthritis requiring imminent joint replacement.
- Moderate arthritis that does not preclude physical activity is not a reason for ineligibility
- Psychiatric disorders or conditions that would preclude participation in the study intervention (e.g. untreated major depression or psychosis, substance abuse, severe personality disorder)
Where
2 sites, 1 recruiting
Dana Farber Cancer Institute
Boston, Massachusetts, United States
Brigham and Women's Hospital
Boston, Massachusetts, United States
Contact
-
Jennifer Ligibel, MD
617-632-3800 jennifer_ligibel@dfci.harvard.edu
-
Anna Tanasijevic, MPH
617-632-5584 anna_tanasijevic@dfci.harvard.edu
Potential match only. Final eligibility is determined by the study team.